MPOX, formerly known as monkeypox until the WHO renamed it in November 2022 to avoid stigma, is resurging, particularly in Africa. On August 14, 2024, WHO declared a Public Health Emergency of International Concern (PHEIC) due to a sharp rise in cases in the Democratic Republic of the Congo (DRC) and neighbouring countries, including Burundi, Kenya, Rwanda, and Uganda. This is the second time in history (the first being in 2022 also for mpox) that a PHEIC has been declared for a DNA virus outbreak, highlighting the urgent need for coordinated global efforts to control the virus.